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AMD Research – Part 2

macular degenerationScientists are putting significant focus on Age-Related Macular Degeneration in their research. This eye disease strikes mostly older adults, over aged 50. The “Baby Boomer” generation is well above age 50, as are their living parents. Understanding the causes and potential treatments for Macular Denegation (ARMD) are important, because vision-impaired elderly people need extra help with their daily activities. Also, quality of life is lowered when vision is poor.

The macula is a tiny yellowish spot in the back of the eye, on the retina. It allows for central vision. Central vision is possible because of the macula. If it breaks down, reading, writing, watching TV, cooking, driving and even facial recognition are impaired. Macular Degeneration is degenerative, meaning that it gets worse over time.

ARMD comes in two forms. The more common
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Avoid Eye Injections for Macular Degeneration with Encapsulated Cell Therapy (ECT)

new implantClinical trials are underway for an implantable device that delivers medication directly to the eyes of people with age-related macular degeneration. Current treatment involves eye injections every four-to-eight weeks, which is difficult to comply with and can create complications. The new technology is a tiny device that is put into the eye and lasts up to 2 years, reducing or eliminating the need for the injections. The devices are being developed by Cumberland, Rhode Island-based Neurotech.
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Genetic Variant and Vitamin D Deficiency Linked to Macular Degeneration

scientific researchWomen with specific genes may be more likely to develop age-related macular degeneration (AMD) if they are deficient in Vitamin D, according to new research in JAMA Ophthalmology.

The genetic variant (Y402H) studied is the complement factor H gene, called CFH for short. The genes in question are related to the immune system. The development of macular degeneration is believed to involve inflammation. In AMD, drusen, lipids (fats) and proteins build up in the eye. The body perceives the drusen to be an invader and attacks it. The genes appear to cause a stronger immune response.
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Fighting Blindness with Gene Therapy, Stem Cells, Bionics

scientist beaker 200Many advances in technology that could improve the lives of blind people are on the horizon. Solutions that were thought impossible not long ago are now becoming a reality for many patients suffering from retinal diseases. Treatments such as gene therapy, stem cells, and bionic retinas have shown that vision loss can in fact be reversible.

Common degenerative diseases of the retina, like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), affect tens of millions of people worldwide, but blindness resulting from these conditions had previously been considered irreversible.
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Oxford Eye Surgeons use Gene Therapy to Treat Eye Disease

gene therapy

The six patients had severe vision loss from choroideremia, a form of retinopathy that is genetic. The disease is fairly rare and manifests only in males. The cells at the back of the eye gradually die, leading to gradual vision loss and ultimately, blindness. Working copies of the faulty gene were injected into retina cells, along with a fluid to halt further degeneration.

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Human Embryonic Cells Used to Create a Retina

Scientists at UC Irvine have created an early stage retina from human embryonic stem cells.  It is the first three-dimensional tissue structure to be made from stem cells and bring us closer to the development of transplant-ready retinas to treat eye disorders such as retinitis pigmentosa and macular degeneration that…
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New Macular Degeneration Research: Scientists Grow New Retinal Cells

Researchers at the University of Wisconsin have successfully grown light-sensing retinal cells from human skin cells.  The ability to grow retinal cells may someday be used to treat degenerative eye diseases such as macular degeneration and retinitis pigmentosa by enabling doctors to repair damage to the retina with new cells…
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